Article
The spectrum of beta-thalassaemia mutations on the Indian subcontinent: the basis for prenatal diagnosis.
British journal of haematology - 1 Jun 1991
Varawalla N Y, Old J M, Sarkar R, Venkatesan R, Weatherall D J
Abstract excerpt
The beta-thalassaemia mutations in 702 unrelated carriers originating from seven different regions of the Indian subcontinent have been characterized using allele specific priming of the polymerase chain reaction (PCR). It was possible to identify the mutations in 688 (98%) of the individuals studied. Eleven different mutations were identified, of which five common ones accounted for 93.6%; namely the ones at...
Topics
- Alleles
- Bangladesh
- Base Sequence
- DNA
- Female
- Humans
- India
- Male
- Molecular Sequence Data
- Mutation
- Oligonucleotides
- Pakistan