Article
Insertional mutations in the yeast HOP1 gene: evidence for multimeric assembly in meiosis.
Genetics - 1 Feb 1994
Friedman D B, Hollingsworth N M, Byers B
Abstract excerpt
The HOP1 gene of Saccharomyces cerevisiae has been shown to play an important role in meiotic synapsis. In this study we analyzed the mechanism of this function by phenotypic characterization of novel in-frame linker-insertion mutations located at various sites throughout the HOP1 coding sequence. Among 12 mutations found to cause defects in meiotic recombination and spore viability, three were...
Topics
- Alleles
- Base Sequence
- DNA-Binding Proteins
- Fungal Proteins
- Genes, Fungal
- Genetic Complementation Test
- Meiosis
- Molecular Sequence Data
- Mutagenesis, Insertional
- Phenotype
- Protein Conformation