Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Fib420: a normal human variant of fibrinogen with two extended alpha chains.

Proceedings of the National Academy of Sciences of the United States of America - 29 Mar 1994

Fu Y, Grieninger G

Abstract excerpt

In fibrinogen, alpha E chains form a subpopulation of alpha subunits that are distinguished by a carboxyl extension homologous to the C termini of the other two constituent chains: beta and gamma. The molecular mass of alpha E is > 50% greater than that of the common alpha subunit, due in part to an extra 236 amino acids. These residues are encoded by exon VI, a recently discovered extension of the fibrinogen...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exons
Share to SDS gene
Share to Genetic Variation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Models, Molecular

Share to Protein Conformation

Share to Protein Processing, Post-Translational

Share to Recombinant Proteins

Share to Tumor Cells, Cultured

Source

Open in PubMed Open full text

Identifiers

PMID: 8146165
DOI: 10.1073/pnas.91.7.2625
PMCID: PMC43422

Genes

SDS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Fib420: a normal human variant of fibrinogen with two extended alpha chains.PMID 8146165Read ↗

Carboxy-terminal-extended variant of the human fibrinogen .alpha. subunit: a novel exon conferring marked homology to .beta. and .gamma. subunitsSemantic proximity Read ↗

Fibulins: physiological and disease perspectivesSemantic proximity Read ↗

Novel fibrinogen (B β401Gly→Val) presents as dys- or hypodysfibrinogenaemia due to alterations in sialic acid content.Semantic proximity Read ↗

Factor B (BF) nomenclature statement.Semantic proximity Read ↗

Biophysical and structural studies of fibulin-2Semantic proximity Read ↗

Fibrinogen Leipzig II (gamma351Gly-->Ser and gamma82Ala-->Gly): hypodysfibrinogenaemia due to two independent amino acid substitutions within the same polypeptide chain.Semantic proximity Read ↗

Exon skipping and aberrant signal peptide cleavage produce novel fibrinogen with an Aα chain lacking the first 42 residues.Semantic proximity Read ↗

Recombinant γY278H Fibrinogen Showed Normal Secretion from CHO Cells, but a Corresponding Heterozygous Patient Showed HypofibrinogenemiaSemantic proximity Read ↗

Fibrinogen brescia: hepatic endoplasmic reticulum storage and hypofibrinogenemia because of a gamma284 Gly-->Arg mutation.Semantic proximity Read ↗

A cluster of basic amino acid residues in the gamma370-381 sequence of fibrinogen comprises a binding site for platelet integrin alpha(IIb)beta3 (glycoprotein IIb/IIIa).Semantic proximity Read ↗

Dimer model for the microfibrillar protein fibulin-2 and identification of the connecting disulfide bridge.Semantic proximity Read ↗

Recombinant variant fibrinogens substituted at residues gamma326Cys and gamma339Cys demonstrated markedly impaired secretion of assembled fibrinogen.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.