Article
Comparison of mutants of Toxoplasma gondii selected for resistance to azithromycin, spiramycin, or clindamycin.
Antimicrobial agents and chemotherapy - 1 Jan 1994
Pfefferkorn E R, Borotz S E
Abstract excerpt
Azithromycin and spiramycin markedly inhibited the growth of Toxoplasma gondii in cultured human fibroblasts. However, 3 days of treatment were required to reveal their full antitoxoplasma activity. This delayed onset of inhibition was similar to that previously reported for clindamycin. Mutants of T. gondii resistant to azithromycin (AziR-1) and spiramycin (SprR-1) were isolated and compared with a previously...
Topics
- Animals
- Azithromycin
- Cells, Cultured
- Clindamycin
- Drug Resistance, Microbial
- Fibroblasts
- Humans
- Leucine
- Mutation
- Oxygen Consumption
- Ribosomes
- Spiramycin