Article
Calcitonin directly acts on mouse osteoblastic MC3T3-E1 cells to stimulate mRNA expression of c-fos, insulin-like growth factor-1 and osteoblastic phenotypes (type 1 collagen and osteocalcin).
Biochemical and biophysical research communications - 15 Mar 1994
Kobayashi T, Sugimoto T, Saijoh K, Fukase M, Chihara K
Abstract excerpt
The present study was performed to examine whether calcitonin directly acted on mouse osteoblastic MC3T3-E1 cells to stimulate the mRNA expression of insulin-like growth factor-1 (IGF-1) and c-fos, followed by an increase in their proliferation and differentiation. Eel calcitonin increased [3H]thymidine incorporation and alkaline phosphatase activity as well as the mRNA expression of type 1 collagen and...
Topics
- Animals
- Calcitonin
- Cell Division
- Cell Line
- Collagen
- Dose-Response Relationship, Drug
- Gene Expression
- Genes, fos
- Insulin-Like Growth Factor I
- Kinetics