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Human pharmacogenomics: The development of a science

1 Jan 2004

Abstract excerpt

Until about 50 years ago, the altering of a normal drug effect by a genetic deficiency was only rarely observed. Here, my discovery of the genetic variant of butyrylcholinesterase affecting succinylcholine action is described in some detail. Such discoveries led to the combination of the two older sciences, genetics and pharmacology, thereby forming pharmacogenetics. After the discovery of similar examples in the...

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PMID: 15588498
DOI: 10.1186/1479-7364-1-5-375

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