Article
Deficiency in fertilization by morphologically abnormal sperm produced by azh mutant mice.
Molecular reproduction and development - 1 Jan 1994
Meistrich M L, Kasai K, Olds-Clarke P, MacGregor G R, Berkowitz A D, Tung K S
Abstract excerpt
Male mice homozygous for the azh mutation produce spermatozoa with abnormal head shapes and have significantly reduced fecundity, to between 5% and 10% that of wild-type or heterozygous mice. Several possible causes of this infertility were investigated. No gross endocrine disorders in azh/azh male mice were observed, and they exhibited apparently normal mating behavior. In addition, their sperm were motile, were...
Topics
- Animals
- Crosses, Genetic
- Female
- Fertility
- Fertilization
- Fertilization in Vitro
- Genotype
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred Strains
- Mice, Mutant Strains