Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII.

1 Mar 1994

Abstract excerpt

The interaction between human factor IXa and factor VIII or its constituent units was investigated. Equilibrium binding studies were performed employing factor VIII light chain that was immobilized on a monoclonal antibody. Factor VIII light chain was observed to bind factor IXa with high affinity (Kd = 14.8 +/- 3.2 nM) and approximately 1:1 stoichiometry. Optimal interaction required NaCl concentrations below...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Coagulation and Thrombosis Mechanisms
Share to Coagulation, Bradykinin, Polyphosphates, and Angioedema
Share to Hemophilia Treatment and Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8125924
DOI: 10.1016/s0021-9258(17)37260-5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Identification of a binding site for blood coagulation factor IXa on the light chain of human factor VIII.PMID 8125924Read ↗

The role of the first growth factor domain of human factor IXa in binding to platelets and in factor X activation.Semantic proximity Read ↗

Ca2+ Binding to the First Epidermal Growth Factor-like Domain of Human Blood Coagulation Factor IX Promotes Enzyme Activity and Factor VIII Light Chain BindingSemantic proximity Read ↗

Characterization of a heparin binding site on the heavy chain of factor XI.Semantic proximity Read ↗

Comparative platelet binding and kinetic studies with normal and variant factor IXa molecules.Semantic proximity Read ↗

Contribution of Factor VIII A2 Domain Residues 400-409 to a Factor X-Interactive Site in the Factor Xase Complex.Semantic proximity Read ↗

Heparin modulates the 99-loop of factor IXa: effects on reactivity with isolated Kunitz-type inhibitor domains.Semantic proximity Read ↗

Surface loop 199-204 in blood coagulation factor IX is a cofactor-dependent site involved in macromolecular substrate interaction.Semantic proximity Read ↗

Activation of a recombinant human factor VII structural analogue alters its affinity of binding to tissue factor.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.