Article
Differences in purine metabolism in patients with Down's syndrome.
Journal of intellectual disability research : JIDR - 1 Dec 1993
Peeters M A, Megarbane A, Cattaneo F, Rethore M O, Lejeune J
Abstract excerpt
Three enzymes intervening in de novo purine synthesis, as well as cystathionine B-synthetase, have been mapped to chromosome 21. In order to gain a better understanding of purine synthesis anomalies in Down's syndrome, the present authors studied the variations in mitotic index of lymphocyte cult...
Topics
- Adenosine
- Adolescent
- Child
- Chromosomes, Human, Pair 21
- Down Syndrome
- Female
- Folic Acid
- Guanosine
- Humans
- Inosine
- Male
- Mitotic Index
- Phenotype