Article
Glucocorticoid independence of acute thymic involution induced by lymphotoxin and estrogen.
Cellular immunology - 1 Feb 1994
Hirahara H, Ogawa M, Kimura M, Iiai T, Tsuchida M, Hanawa H, Watanabe H, Abo T
Abstract excerpt
Acute thymic involution is known to be induced under conditions of physical stress, bacterial infections, and malignancies. It is speculated that glucocorticoids, tumor necrosis factor (TNF), and other factors may act as mediators for the thymic involution under such conditions. It was herein investigated whether either lymphotoxin (TNF beta) or estrogen could induce thymic involution without the help of...
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