Article
Effect of mutational alteration of Asn-128 in the putative GTP-binding domain of tetracycline resistance determinant Tet(O) from Campylobacter jejuni.
Antimicrobial agents and chemotherapy - 1 Dec 1993
Grewal J, Manavathu E K, Taylor D E
Abstract excerpt
The deduced amino acid sequence of Campylobacter jejuni Tet(O), cloned in Escherichia coli, has shown that it contains the five highly conserved sequences of the GTP-binding domain found in other GTPases. Asn-128 belongs to the G4 motif of such a domain and is involved in hydrogen bonding with th...
Topics
- Amino Acid Sequence
- Asparagine
- Binding Sites
- Campylobacter jejuni
- GTP-Binding Proteins
- Molecular Sequence Data
- Mutagenesis, Site-Directed
- Mutation
- Peptide Biosynthesis
- Peptides
- Poly U
- Ribosomes
- Tetracycline Resistance
- Tetracyclines