Article
Genetic interaction between the Ras-cAMP pathway and the Dis2s1/Glc7 protein phosphatase in Saccharomyces cerevisiae.
Molecular & general genetics : MGG - 1 Feb 1994
Matsuura A, Anraku Y
Abstract excerpt
The Saccharomyces cerevisiae DIS2S1/GLC7 gene encodes a type 1 protein phosphatase indispensable for cell proliferation. We found that introduction of a multicopy DIS2S1 plasmid impaired growth of cells with reduced activity of the cAMP-dependent protein kinase. In order to understand further the interaction between the two enzymes, a temperature-sensitive mutation in the DIS2S1 gene was isolated. The mutant...
Topics
- 3',5'-Cyclic-AMP Phosphodiesterases
- Amino Acid Sequence
- Animals
- Cyclic AMP
- Cyclic AMP-Dependent Protein Kinases
- Fungal Proteins
- Genes, Fungal
- Mice
- Molecular Sequence Data
- Multigene Family
- Mutation