Article
Swaledale sheep affected by natural scrapie differ significantly in PrP genotype frequencies from healthy sheep and those selected for reduced incidence of scrapie.
The Journal of general virology - 1 Jun 1993
Hunter N, Goldmann W, Benson G, Foster J D, Hope J
Abstract excerpt
PrP glycoprotein gene polymorphisms were examined in Swaledale sheep affected by natural scrapie, in healthy sheep and in Swaledales selected for low susceptibility to scrapie. The three groups differed significantly in frequencies of PrP genotypes detected by the restriction enzymes EcoRI, HindI...
Topics
- Age Factors
- Animals
- Deoxyribonuclease HindIII
- Genetic Predisposition to Disease
- Genetic Variation
- Genotype
- Immunity, Innate
- Incidence
- Polymorphism, Genetic
- PrPSc Proteins
- Prions
- Restriction Mapping
- Scrapie
- Selection, Genetic
- Sequence Analysis, DNA
- Sheep
- Species Specificity