Article
Vertebrate opsins belonging to different classes vary in constitutively active properties resulting from salt-bridge mutations.
Biochemistry - 13 Jun 2006
Nickle Benjamin, Wilkie Susan E, Cowing Jill A, Hunt David M, Robinson Phyllis R
Abstract excerpt
Vertebrate opsins are classified into one of five classes on the basis of amino acid similarity. These classes are short wavelength sensitive 1 and 2 (SWS1, SWS2), medium/long wavelength sensitive (M/LWS), and rod opsin like 1 and 2 (RH1, RH2). In bovine rod opsin (RH1), two critical amino acids form a salt bridge in the apoprotein that maintains the opsin in an inactive state. These residues are K296, which...
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