Article
Immunology of atherosclerosis. Demonstration of heat shock protein 60 expression and T lymphocytes bearing alpha/beta or gamma/delta receptor in human atherosclerotic lesions.
The American journal of pathology - 1 Jun 1993
Kleindienst R, Xu Q, Willeit J, Waldenberger F R, Weimann S, Wick G
Abstract excerpt
Our previous work revealed the presence of a great number of activated T lymphocytes in early human atherosclerotic lesions, and we were able to induce atherosclerosis in normocholesterolemic rabbits by immunization with Mycobacterium tuberculosis heat-shock protein (HSP) 65. We hypothesized this latter phenomenon to arise from cross-reactivity of mycobacterial HSP 65 with the endogenously expressed homologous...
Topics
- Adult
- Aged
- Aged, 80 and over
- Antibodies, Monoclonal
- Aorta
- Arteriosclerosis
- Carotid Arteries
- Chaperonin 60
- Endothelium, Vascular
- Enzyme-Linked Immunosorbent Assay