[Genetic defect of the hyperbilirubinemic Gunn rat, a model for Crigler-Najjar syndrome type I].

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Article

[Genetic defect of the hyperbilirubinemic Gunn rat, a model for Crigler-Najjar syndrome type I].

Nihon rinsho. Japanese journal of clinical medicine - 1 Feb 1993

Sato H, Aono S, Koiwai O

Abstract excerpt

The hyperbilirubinemic Gunn rat lacks hepatic UDP-glucuronosyltransferase (UDPGT) activity toward bilirubin and has been used as an animal model for human Crigler-Najjar syndrome type I. Rat liver bilirubin UDPGT cDNA was isolated. The cDNA shared an identical 913-bp sequence (corresponding to th...

Topics

Amino Acid Sequence
Animals
Base Sequence
Chromosome Mapping
Crigler-Najjar Syndrome
DNA
DNA Probes
Disease Models, Animal
Glucuronosyltransferase
Humans
Molecular Sequence Data
Mutation
Polymorphism, Restriction Fragment Length
Rats
Rats, Gunn

Source

Open in PubMed

Identifiers

PMID: 8096554

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8096554-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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