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Article

Mechanisms of inherited deficiencies of multiple UDP‐glucuronosyltransferase isoforms in two patients with Crigler‐Najjar syndrome, type I

1 Jul 1992

Abstract excerpt

Crigler‐Najjar syndrome, type I (CN‐I) is a potentially lethal disorder characterized by severe unconjugated hyperbilirubinemia resulting from a recessively inherited deficiency of hepatic UDP‐glucuronosyltransferase (UGT) activity toward bilirubin (B‐UGT). Two forms of B‐UGT exist in human liver. mRNAs for these two forms and that for another isoform with activity toward simple phenols (P‐UGT) have unique 5′...

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Identifiers

PMID: 1634050
DOI: 10.1096/fasebj.6.10.1634050

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Mechanisms of inherited deficiencies of multiple UDP‐glucuronosyltransferase isoforms in two patients with Crigler‐Najjar syndrome, type IPMID 1634050Read ↗

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