Article
Polymorphic haplotypes and recombination rates at the LDL receptor gene locus in subjects with and without familial hypercholesterolemia who are from different populations.
American journal of human genetics - 1 Apr 1993
Miserez A R, Schuster H, Chiodetti N, Keller U
Abstract excerpt
RFLPs at the low-density lipoprotein (LDL) receptor locus for TaqI, StuI, HincII, AvaII, ApaLI (5' and 3'), PvuII, and NcoI were studied in Swiss and German families with familial hypercholesterolemia (FH). A total of 1,104 LDL receptor alleles were analyzed using Southern blotting and new PCR-ba...
Topics
- Base Sequence
- Biological Evolution
- Chi-Square Distribution
- DNA Mutational Analysis
- DNA Restriction Enzymes
- Ethnicity
- Female
- Gene Frequency
- Genetic Variation
- Genetics, Population
- Germany
- Haplotypes
- Humans
- Hyperlipoproteinemia Type II
- Italy
- Japan
- Linkage Disequilibrium
- Male