Article
Transformation-induced alterations in the regulation of tyrosine aminotransferase expression in fetal rat hepatocytes: changes in hormone inducibility and the DNase-hypersensitive site.
Cancer research - 1 Feb 1993
Yeoh G C, Fisher C J
Abstract excerpt
Regulation of expression of tyrosine aminotransferase (TAT) is examined in two cell lines (FRL) obtained by chemical transformation of cultured fetal hepatocytes derived from 19-day rat fetuses (FL19). Steroid induction of TAT is unaffected by transformation, while the response to cyclic AMP is a...
Topics
- Animals
- Binding Sites
- Cell Differentiation
- Cell Transformation, Neoplastic
- Cells, Cultured
- Chromatin
- Deoxyribonuclease I
- Enzyme Induction
- Fetus
- Gene Expression Regulation, Enzymologic
- Genes, tat
- Hormones
- Liver
- Phenotype
- RNA, Messenger
- Rats
- Sensitivity and Specificity
- Transcription, Genetic