Article
Mutation induction by ionizing radiation in three human bladder tumour cell lines.
International journal of radiation biology - 1 Jan 1993
Kent C R, Edwards S M, McMillan T J
Abstract excerpt
Mutation induction at the hypoxanthine-guanine phosphoribosyl transferase (hprt) locus has been studied in three human bladder tumour cell lines of varying radiosensitivity. U1-S40b, a radiosensitive mutant clone of MGH-U1, has been previously reported to show no difference in split-dose recovery or low dose-rate sparing, but to have an impaired repair fidelity when compared to its parent line. In this paper we...
Topics
- Carcinoma, Transitional Cell
- Cell Survival
- Cobalt Radioisotopes
- Dose-Response Relationship, Radiation
- Gamma Rays
- Humans
- Hypoxanthine Phosphoribosyltransferase
- In Vitro Techniques
- Mutation
- Radiation Effects
- Tumor Cells, Cultured