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Article

Lethality and mutagenesis of B lymphocyte progenitor cells following exposure to alpha-particles and X-rays.

International journal of radiation biology - 1 Aug 1994

Griffiths S D, Marsden S J, Wright E G, Greaves M F, Goodhead D T

Abstract excerpt

B lymphocyte precursor cells are the target cells for the major subtype of paediatric cancer, acute lymphoblastic leukaemia. Using a murine IL-7-dependent clonogenic assay for normal B cell precursors as a model, we have investigated the sensitivity of these cells versus other normal and leukaemi...

Topics

Alpha Particles
Animals
B-Lymphocytes
Cell Death
Cell Transformation, Neoplastic
Energy Transfer
Hematopoietic Stem Cells
Hypoxanthine Phosphoribosyltransferase
Mice
Mice, Inbred BALB C
Mutagenesis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Plutonium

Radiation Tolerance

X-Rays

Source

Identifiers

PMID: 8089629
DOI: 10.1080/09553009414551101

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8089629-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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