Article
A multicopy dinucleotide marker that maps close to the spinal muscular atrophy gene.
Genomics - 15 May 1994
Burghes A H, Ingraham S E, McLean M, Thompson T G, McPherson J D, Kote-Jarai Z, Carpten J D, DiDonato C J, Ikeda J E, Surh L
Abstract excerpt
Spinal muscular atrophy (SMA) is a common autosomal recessive disorder resulting in loss of motor neurons. The interval containing the SMA gene has been defined by linkage analysis as 5qcen-D5S435-SMA-D5S557-5qter. We have isolated a new dinucleotide repeat marker, CATT1, that lies between these...
Topics
- Alleles
- Animals
- Base Sequence
- Canada
- Cells, Cultured
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- DNA Primers
- Female
- Genetic Linkage
- Genetic Markers
- Humans
- Hybrid Cells
- Male
- Molecular Sequence Data
- Muscular Atrophy, Spinal
- Pedigree
- Polymerase Chain Reaction