Article
Two 5q13 simple tandem repeat loci are in linkage disequilibrium with type 1 spinal muscular atrophy.
Human molecular genetics - 1 Nov 1994
McLean M D, Roy N, MacKenzie A E, Salih M, Burghes A H, Simard L, Korneluk R G, Ikeda J E, Surh L
Abstract excerpt
The gene for the common recessive neuromuscular disorder spinal muscular atrophy (SMA) has been previously mapped to chromosome 5q. We report here linkage disequilibrium analyses of two polymorphic simple tandem repeat (STR) sequences which map into the critical region of 5q13 containing the SMA...
Topics
- Alleles
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Humans
- Linkage Disequilibrium
- Molecular Sequence Data
- Phenotype
- Polymerase Chain Reaction
- Repetitive Sequences, Nucleic Acid
- Spinal Muscular Atrophies of Childhood