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Article

Spontaneous generation of infectious nucleating amyloids in the transmissible and nontransmissible cerebral amyloidoses.

Molecular neurobiology - 1 Feb 1994

Gajdusek D C

Abstract excerpt

The unconventional viruses of the transmissible subacute spongiform encephalopathies (kuru-CJD-GSS-FFI-scrapie-BSE) are nucleants spontaneously generated from host precursor proteins altered to beta-pleated sheet configuration that polymerize into insoluble infectious amyloid fibrils. The de novo conversion to infectious amyloids is facilitated or accelerated by many different point mutations causing amino acid...

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Identifiers

PMID: 8086124
DOI: 10.1007/BF02778003

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GSS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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