Article
Spontaneous generation of infectious nucleating amyloids in the transmissible and nontransmissible cerebral amyloidoses.
Molecular neurobiology - 1 Feb 1994
Gajdusek D C
Abstract excerpt
The unconventional viruses of the transmissible subacute spongiform encephalopathies (kuru-CJD-GSS-FFI-scrapie-BSE) are nucleants spontaneously generated from host precursor proteins altered to beta-pleated sheet configuration that polymerize into insoluble infectious amyloid fibrils. The de novo...
Topics
- Alzheimer Disease
- Amyloid
- Amyloid Neuropathies
- Amyloid beta-Protein Precursor
- Amyloidosis
- DNA Mutational Analysis
- Ethnicity
- Genes
- Genetic Predisposition to Disease
- Global Health
- Humans
- Incidence
- Point Mutation
- Polymers
- Prealbumin
- Prion Diseases
- Protein Folding
- Protein Processing, Post-Translational