Gene amplification and multiple mutations of the K-ras oncogene in Kaposi's sarcoma.

Article

Gene amplification and multiple mutations of the K-ras oncogene in Kaposi's sarcoma.

Anticancer research - 1 Jan 2000

Nicolaides A, Huang Y Q, Li J J, Zhang W G, Friedman-Kien A E

Abstract excerpt

Thirty one biopsy samples of fresh Kaposi's sarcoma (KS) skin lesions were examined for alteration of the K-ras oncogene by differential PCR, SSCP and nucleic acid sequencing. Three KS specimens showed amplification of K-ras and 7 were found to have various mutations at exon 1 of the K-ras gene....

Topics

Base Sequence
Genes, ras
Humans
Molecular Sequence Data
Mutation
Polymerase Chain Reaction
Sarcoma, Kaposi

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