Article
Engineering poliovirus as a vaccine vector for the expression of diverse antigens
2 Sept 1994
Abstract excerpt
As a step toward developing poliovirus as a vaccine vector, poliovirus recombinants were constructed by fusing exogenous peptides (up to 400 amino acids) and an artificial cleavage site for viral protease 3Cpro to the amino terminus of the viral polyprotein. Viral replication proceeded normally. An extended polyprotein was produced in infected cells and proteolytically processed into the complete array of viral...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.