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Article

The control region of the pdu/cob regulon in Salmonella typhimurium.

Journal of bacteriology - 1 Sept 1994

Chen P, Andersson D I, Roth J R

Abstract excerpt

The pdu operon encodes proteins for the catabolism of 1,2-propanediol; the nearby cob operon encodes enzymes for the biosynthesis of adenosyl-cobalamin (vitamin B12), a cofactor required for the use of propanediol. These operons are transcribed divergently from distinct promoters separated by several kilobases. The regulation of the two operons is tightly integrated in that both require the positive activator...

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Identifiers

PMID: 8071226
DOI: 10.1128/jb.176.17.5474-5482.1994
PMCID: PMC196736

Genes

MIP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The control region of the pdu/cob regulon in Salmonella typhimurium.PMID 8071226Read ↗

Repression of the cob operon of Salmonella typhimurium by adenosylcobalamin is influenced by mutations in the pdu operon.Semantic proximity Read ↗

Two global regulatory systems (Crp and Arc) control the cobalamin/propanediol regulon of Salmonella typhimurium.Semantic proximity Read ↗

Functional genomic, biochemical, and genetic characterization of the Salmonella pduO gene, an ATP:cob(I)alamin adenosyltransferase gene.Semantic proximity Read ↗

Cobalamin-dependent 1,2-propanediol utilization by Salmonella typhimurium.Semantic proximity Read ↗

Characterization of the PduS cobalamin reductase of Salmonella enterica and its role in the Pdu microcompartment.Semantic proximity Read ↗

The cobC gene of Salmonella typhimurium codes for a novel phosphatase involved in the assembly of the nucleotide loop of cobalamin.Semantic proximity Read ↗

Cobalamin (vitamin B12) repression of the Cob operon in Salmonella typhimurium requires sequences within the leader and the first translated open reading frame.Semantic proximity Read ↗

CobB, a new member of the SIR2 family of eucaryotic regulatory proteins, is required to compensate for the lack of nicotinate mononucleotide:5,6-dimethylbenzimidazole phosphoribosyltransferase activity in cobT mutants during cobalamin biosynthesis in Salmonella typhimurium LT2.Semantic proximity Read ↗

cobA function is required for both de novo cobalamin biosynthesis and assimilation of exogenous corrinoids in Salmonella typhimurium.Semantic proximity Read ↗

Signal-dependent requirement for the co-activator protein RcsA in transcription of the RcsB-regulated ugd gene.Semantic proximity Read ↗

Identification of a new prp locus required for propionate catabolism in Salmonella typhimurium LT2.Semantic proximity Read ↗

High levels of transcription factor RpoS (sigma S) in mviA mutants negatively affect 1,2-propanediol-dependent transcription of the cob/pdu regulon of Salmonella typhimurium LT2.Semantic proximity Read ↗

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