Clonality studies and N-ras and p53 mutation analysis of hematopoietic cells in Fanconi anemia.

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Article

Clonality studies and N-ras and p53 mutation analysis of hematopoietic cells in Fanconi anemia.

Leukemia - 1 Aug 1994

Venkatraj V S, Gaidano G, Auerbach A D

Abstract excerpt

Patients with Fanconi anemia (FA) have an extraordinary predisposition to acute myelogenous leukemia (AML). The genetic mechanisms underlying the neoplastic transformation of FA hematopoietic cells are unknown. In this study, we have investigated the molecular features of hematopoiesis in the course of FA at different stages of the disease, including aplastic anemia, myelodysplastic syndrome (MDS), and AML. The...

Topics

Base Sequence
Bone Marrow
Clone Cells
Exons
Fanconi Anemia
Female
Genes, p53
Genes, ras
Hematopoiesis
Hematopoietic Stem Cells
Humans
Leukemia, Myeloid, Acute

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Mutation

Myelodysplastic Syndromes

Polymerase Chain Reaction

Polymorphism, Genetic

Reference Values

Source

Open in PubMed

Identifiers

PMID: 8057673

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8057673-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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