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Article

Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction.

1 Aug 1991

Abstract excerpt

The myeloproliferative syndromes are acquired disorders of hematopoiesis that provide insights into the transition from somatic cell mutation to neoplasia. The clonal origin of specific blood cells can be assessed in patients with X chromosome-linked polymorphisms, taking advantage of random inactivation of the X chromosome. We have adapted the PCR for determination of clonality on as few as 100 cells, including...

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Identifiers

PMID: 1862109
DOI: 10.1073/pnas.88.15.6848

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Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction.PMID 1862109Read ↗

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