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Article

Role of mgrA and sarA in methicillin-resistant Staphylococcus aureus autolysis and resistance to cell wall-active antibiotics.

The Journal of infectious diseases - 15 Jan 2009

Trotonda María Pilar, Xiong Yan Q, Memmi Guido, Bayer Arnold S, Cheung Ambrose L

Abstract excerpt

BACKGROUND: We have previously shown the importance of mgrA and sarA in controlling autolysis of Staphylococcus aureus, with MgrA and SarA both being negative regulators of murein hydrolases. METHODS: In this study, we analyzed the effects of mgrA and sarA on antibiotic-mediated lysis in vitro and on the responses to cell wall-active antibiotic therapy in an experimental endocarditis model by use of 2...

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Source

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Identifiers

PMID: 19072553
DOI: 10.1086/595740
PMCID: PMC2782823

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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