Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activity.

doi:10.1016/0304-3835(94)90015-9

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Article

Effects of isothiocyanate alkyl chain-length on hamster liver cytochrome P-450 activity.

Cancer letters - 29 Jul 1994

Hamilton S M, Zhang Z, Teel R W

Abstract excerpt

The tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is metabolized by various isozymes of cytochrome P-450 present in microsomes. In this study, we examined the effects of the isothiocyanate homologues, phenyl isothiocyanate (PITC), benzyl isothiocyanate (BITC),...

Topics

Animals
Cricetinae
Cytochrome P-450 Enzyme System
Isothiocyanates
Male
Mesocricetus
Mice
Microsomes, Liver
Mutagenicity Tests
Mutation
Nitrosamines
Oxidation-Reduction
Rats
Rats, Inbred F344
Testosterone
Thiocyanates

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