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Article

Increased expression of perforin and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2.

Cancer immunology, immunotherapy : CII - 1 Jul 1994

Leger-Ravet M B, Mathiot C, Portier A, Brandely M, Galanaud P, Fridman W H, Emilie D

Abstract excerpt

The frequency of peripheral blood cells expressing the perforin gene or the granzyme B gene was evaluated by in situ hybridization in nine patients suffering from metastatic melanoma and treated with recombinant interleukin-2 (rIL-2). A spontaneous expression of both genes was detected in five to seven patients. rIL-2 administration increased the frequency of positive cells in all patients (P < 0.03 for each...

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Identifiers

PMID: 8044827
DOI: 10.1007/BF01517181
PMCID: PMC11038965

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Source receipt: pubmed, retrieved 7 Sept 2026.

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