Article
Increased expression of perforin and granzyme B genes in patients with metastatic melanoma treated with recombinant interleukin-2.
Cancer immunology, immunotherapy : CII - 1 Jul 1994
Leger-Ravet M B, Mathiot C, Portier A, Brandely M, Galanaud P, Fridman W H, Emilie D
Abstract excerpt
The frequency of peripheral blood cells expressing the perforin gene or the granzyme B gene was evaluated by in situ hybridization in nine patients suffering from metastatic melanoma and treated with recombinant interleukin-2 (rIL-2). A spontaneous expression of both genes was detected in five to...
Topics
- CD8 Antigens
- Gene Expression
- Granzymes
- Humans
- In Situ Hybridization
- Interleukin-2
- Killer Cells, Natural
- Leukocytes, Mononuclear
- Lymphocytes
- Melanoma
- Membrane Glycoproteins
- Perforin
- Phenotype
- Pore Forming Cytotoxic Proteins
- Recombinant Proteins