Article
Altered expression of surface protein WI-1 in genetically related strains of Blastomyces dermatitidis that differ in virulence regulates recognition of yeasts by human macrophages.
Infection and immunity - 1 Aug 1994
Klein B S, Chaturvedi S, Hogan L H, Jones J M, Newman S L
Abstract excerpt
The molecular basis for pathogenicity and virulence of the dimorphic fungus Blastomyces dermatitidis remains unknown. WI-1 is a major cell wall protein of B. dermatitidis yeasts and is a recognition target of both humoral and cell-mediated immunity. As an initial study to determine if WI-1 might...
Topics
- Antigens, Fungal
- Blastomyces
- Cells, Cultured
- Flow Cytometry
- Fungal Proteins
- Glycoproteins
- Humans
- Macrophages
- Mutation
- Virulence