Article
Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potential.
Biochemical and biophysical research communications - 15 Jul 1994
Qian F, Chan S J, Achkar C, Steiner D F, Frankfater A
Abstract excerpt
The highly metastatic B16a melanoma has been shown to express higher levels of cathepsin B (CB) mRNA when compared to the less metastatic variants, B16-F1 and B16-F10, and with normal mouse tissues. This increased expression is now shown to be due to increased gene transcription by nuclear run-of...
Topics
- Animals
- Base Sequence
- Blotting, Northern
- Cathepsin B
- Cell Nucleus
- DNA Probes
- Gene Expression Regulation, Enzymologic
- Gene Expression Regulation, Neoplastic
- Genetic Variation
- Melanoma, Experimental
- Mice
- Molecular Sequence Data
- Oligodeoxyribonucleotides
- Promoter Regions, Genetic
- RNA, Messenger
- Transcription, Genetic