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Article

Transcriptional regulation of cathepsin B expression in B16 melanomas of varying metastatic potential.

Biochemical and biophysical research communications - 15 Jul 1994

Qian F, Chan S J, Achkar C, Steiner D F, Frankfater A

Abstract excerpt

The highly metastatic B16a melanoma has been shown to express higher levels of cathepsin B (CB) mRNA when compared to the less metastatic variants, B16-F1 and B16-F10, and with normal mouse tissues. This increased expression is now shown to be due to increased gene transcription by nuclear run-off assays and measurements of mRNA stability. Transient expression assays, using promoter fragments from the mouse and...

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Identifiers

PMID: 8037744
DOI: 10.1006/bbrc.1994.1946

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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