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Induction of matrix metalloproteinase gene transcription by nitric oxide and mechanisms of MMP‐1 gene induction in human melanoma cell lines

26 Nov 2002

Abstract excerpt

Expression of 12 matrix metalloproteinases (MMPs) after exposure of human melanoma cell lines C32TG and Mewo to nitric oxide (NO) was investigated by the reverse transcription-polymerase chain reaction. Expression of the mRNA of MMP-1, -3, -10 and -13 in C32TG cells was transcriptionally enhanced in a dose-dependent manner by exposure to an NO donor, S-nitroso-N-acetyl-DL-penicillamine (SNAP) and mRNA expression...

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PMID: 12455029
DOI: 10.1002/ijc.10808

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