Article
Comparative activity of tamoxifen and N-desmethyltamoxifen in human multidrug resistant leukemia cell lines.
Leukemia - 1 Jul 1994
Berman E, McBride M, Tong W
Abstract excerpt
Tamoxifen (Tmx) is one of a number of agents that can reverse the multidrug resistant (MDR) phenotype in vitro; it is unique, however, in that both the parent compound and the main metabolite, N-desmethyltamoxifen (NDMTmx), have long plasma half-lives, 7 and 14 days, respectively. To determine whether NDMTmx was as active as the parent compound in restoring sensitivity to daunorubicin (DNR) in vitro, we performed...
Topics
- Daunorubicin
- Drug Resistance
- Drug Screening Assays, Antitumor
- Humans
- Leukemia, Myeloid
- Phenotype
- Tamoxifen
- Tumor Cells, Cultured