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Article

Synergy and resistance to synergy between beta-lactam antibiotics and glycopeptides against glycopeptide-resistant strains of Enterococcus faecium.

Antimicrobial agents and chemotherapy - 1 Apr 1994

Gutmann L, al-Obeid S, Billot-Klein D, Guerrier M L, Collatz E

Abstract excerpt

A synergistic effect between vancomycin or teicoplanin and different beta-lactam antibiotics was found for two strains of Enterococcus faecium, EFM4 and EFM11, expressing resistance to glycopeptides and belonging to the VANA class. The MICs of penicillin for these two strains were 16 and 128 micrograms/ml, respectively. By using a penicillin-binding protein (PBP) competition assay, it was shown that the...

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Identifiers

PMID: 8031053
DOI: 10.1128/AAC.38.4.824
PMCID: PMC284549

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