Article
Channel catfish herpesvirus (CCV) encodes a functional thymidine kinase gene: elucidation of a point mutation that confers resistance to Ara-T.
Virology - 1 Aug 1994
Hanson L A, Kousoulas K G, Thune R L
Abstract excerpt
The channel catfish herpesvirus (CCV) thymidine kinase (TK) gene was mapped on the CCV genome by marker rescue analysis using a TK-deficient channel catfish ovary cell line (CCO), a TK-negative CCV mutant, and a panel of cloned CCV genomic DNA fragments. The TK-deficient cell line (CCOBr) was iso...
Topics
- Animals
- Arabinonucleosides
- Cell Line
- Cloning, Molecular
- Drug Resistance, Microbial
- Genes, Viral
- Herpesviridae
- Ictaluridae
- Molecular Sequence Data
- Mutation
- Repetitive Sequences, Nucleic Acid
- Thymidine
- Thymidine Kinase
- Transfection
- Viral Structural Proteins