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Article

Channel catfish herpesvirus (CCV) encodes a functional thymidine kinase gene: elucidation of a point mutation that confers resistance to Ara-T.

Virology - 1 Aug 1994

Hanson L A, Kousoulas K G, Thune R L

Abstract excerpt

The channel catfish herpesvirus (CCV) thymidine kinase (TK) gene was mapped on the CCV genome by marker rescue analysis using a TK-deficient channel catfish ovary cell line (CCO), a TK-negative CCV mutant, and a panel of cloned CCV genomic DNA fragments. The TK-deficient cell line (CCOBr) was isolated after repeated propagation of CCO cells in increasing concentrations of 5-bromo-2'-deoxyuridine. Infection of...

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Identifiers

PMID: 8030231
DOI: 10.1006/viro.1994.1387

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