Article
Glycosaminoglycan contributions to both protein C activation and thrombin inhibition involve a common arginine-rich site in thrombin that includes residues arginine 93, 97, and 101.
The Journal of biological chemistry - 8 Jul 1994
Ye J, Rezaie A R, Esmon C T
Abstract excerpt
Proteoglycans play pivotal roles in the regulation of thrombin. Thrombomodulin (TM) binds thrombin through protein-protein contacts and a chondroitin sulfate moiety. The complex activates the anticoagulant zymogen, protein C. Thrombin and a thrombin mutant with Arg93, Arg97, and Arg101 changed to...
Topics
- Animals
- Antithrombins
- Arginine
- Base Sequence
- Binding Sites
- Calcium
- Cattle
- Chondroitin Sulfates
- DNA
- Enzyme Activation
- Glycosaminoglycans
- Heparin
- Humans
- Molecular Sequence Data
- Mutation
- Neutralization Tests
- Protein C
- Prothrombin