Article
Importance of peptide amino and carboxyl termini to the stability of MHC class I molecules.
Science (New York, N.Y.) - 15 Jul 1994
Bouvier M, Wiley D C
Abstract excerpt
An influenza virus matrix peptide in which either the charged amino or carboxyl terminus was substituted by methyl groups promoted folding of the class I human histocompatibility antigen (HLA-A2). A peptide modified at both termini did not promote stable folding. The thermal stability of HLA-A2 c...
Topics
- Amino Acid Sequence
- Binding Sites
- HLA-A2 Antigen
- Humans
- Hydrogen Bonding
- Molecular Sequence Data
- Mutation
- Orthomyxoviridae
- Peptides
- Protein Denaturation
- Protein Folding
- Temperature
- Thermodynamics
- Thermolysin
- Viral Matrix Proteins
- beta 2-Microglobulin