Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Importance of peptide amino and carboxyl termini to the stability of MHC class I molecules.

Science (New York, N.Y.) - 15 Jul 1994

Bouvier M, Wiley D C

Abstract excerpt

An influenza virus matrix peptide in which either the charged amino or carboxyl terminus was substituted by methyl groups promoted folding of the class I human histocompatibility antigen (HLA-A2). A peptide modified at both termini did not promote stable folding. The thermal stability of HLA-A2 complexed with peptides that did not have either terminus was approximately 22 degrees C lower than that of the control...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Binding Sites
Share to Molecular Sequence Data

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Peptides

Share to Protein Folding

Share to Temperature

Share to Thermodynamics

Source

Identifiers

PMID: 8023162
DOI: 10.1126/science.8023162

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Importance of peptide amino and carboxyl termini to the stability of MHC class I molecules.PMID 8023162Read ↗

Amino acid insertion in Bat MHC-I enhances complex stability and augments peptide presentationSemantic proximity Read ↗

Sequence motifs important for peptide binding to the human MHC class I molecule, HLA-A2Semantic proximity Read ↗

Thermodynamic stability of HLA-B*2705. Peptide complexes. Effect of peptide and major histocompatibility complex protein mutations.Semantic proximity Read ↗

Two structural states of complexes of peptide and class II major histocompatibility complex revealed by photoaffinity-labeled peptides.Semantic proximity Read ↗

Relative implication of peptide residues in binding to major histocompatibility complex class I H-2Db: application to the design of high-affinity, allele-specific peptides.Semantic proximity Read ↗

Thermostability profiling of MHC-bound peptides: a new dimension in immunopeptidomics and aid for immunotherapy design.Semantic proximity Read ↗

The contribution of major histocompatibility complex contacts to the affinity and kinetics of T cell receptor binding.Semantic proximity Read ↗

Hydrogen bond integrity between MHC class II molecules and bound peptide determines the intracellular fate of MHC class II molecules.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.