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Article

Inherited glutathione-S-transferase deficiency is a risk factor for pulmonary asbestosis.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Sept 1994

Smith C M, Kelsey K T, Wiencke J K, Leyden K, Levin S, Christiani D C

Abstract excerpt

Pulmonary diseases attributable to asbestos exposure constitute a significant public health burden, yet few studies have investigated potential genetic determinants of susceptibility to asbestos-related diseases. The glutathione-S-transferases are a family of conjugating enzymes that both catalyze the detoxification of a variety of potentially cytotoxic electrophilic agents and act in the generation of...

Topics

Adult
Aged
Asbestosis
Chromosome Deletion
Cohort Studies
Cross-Sectional Studies
Disease Susceptibility
Genes
Genotype
Glutathione Transferase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Homozygote

Humans

Metabolism, Inborn Errors

Middle Aged

Occupational Exposure

Pleural Diseases

Polymorphism, Genetic

Prevalence

Source

Identifiers

PMID: 8000297

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8000297-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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