Article
[Genomic changes in strains of the tick-borne encephalitis virus as a result of passages in mice].
Voprosy virusologii - 1 Jan 2000
Drokin D A, Zlobin V I, Karganova G G, Vikhoreva T V, Iakimenko V V, Dzhivanian T I, Lashkevich V A
Abstract excerpt
Changes in genomes of TBE strains isolated from various sources at early stages of laboratory adaptation to white mice brain were demonstrated by molecular hybridization of nucleic acids with synthetic oligonucleotide probes, complementary RNA sites of reference TBE strains Sofyin and Neudorf. Of the 4 TBE strains passed 6 times through white mice brain in only 1 the level of RNA hybridization with 2...
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