Sequence changes in the pilus subunit lead to tropism variation of Neisseria gonorrhoeae to human tissue.

doi:10.1111/j.1365-2958.1994.tb00435.x

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Article

Sequence changes in the pilus subunit lead to tropism variation of Neisseria gonorrhoeae to human tissue.

Molecular microbiology - 1 Aug 1994

Jonsson A B, Ilver D, Falk P, Pepose J, Normark S

Abstract excerpt

Pili of Neisseria gonorrhoeae are correlated with increased bacterial attachment to epithelial cells and undergo both phase and antigenic variation. Phase variation of gonococcal pili can be brought about by recombination events in the pilin structural gene, pilE, or by the on/off switch in expression of PilC, a pilus biogenesis protein for which two loci exist. We have studied the binding to epithelial cell...

Topics

Amino Acid Sequence
Animals
Bacterial Adhesion
Bacterial Outer Membrane Proteins
Bacterial Proteins
Base Sequence
Cell Line
Epithelium
Fimbriae Proteins
Fimbriae, Bacterial
Genes, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genetic Variation

Humans

Mice

Molecular Sequence Data

Neisseria gonorrhoeae

Organ Specificity

Rats

Source

Open in PubMed

Identifiers

PMID: 7997158
DOI: 10.1111/j.1365-2958.1994.tb00435.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7997158-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Sequence changes in the pilus subunit lead to tropism variation of Neisseria gonorrhoeae to human tissue.PMID 7997158Read ↗

Interaction of two variable proteins (PilE and PilC) required for pilus-mediated adherence of Neisseria gonorrhoeae to human epithelial cells.Semantic proximity Read ↗

Pilus biogenesis and epithelial cell adherence of <i>Neisseria gonorrhoeae pilC</i> double knock‐out mutantsSemantic proximity Read ↗

CD46-Independent Binding of Neisserial Type IV Pili and the Major Pilus Adhesin, PilC, to Human Epithelial CellsSemantic proximity Read ↗

Role of pili and the phase-variable PilC protein in natural competence for transformation of Neisseria gonorrhoeae.Semantic proximity Read ↗

Neisseria gonorrhoeae PilC expression provides a selective mechanism for structural diversity of pili.Semantic proximity Read ↗

Neisseria meningitidis undergoes PilC phase variation and PilE sequence variation during invasive disease.Semantic proximity Read ↗

Antigenic variation of gonococcal pilin expression in vivo: analysis of the strain FA1090 pilin repertoire and identification of the pilS gene copies recombining with pilE during experimental human infection The GenBank accession numbers for the sequences reported in this paper are U58840–U58851, U61269, L28978, L28980, L28987 and L28990–L28992.Semantic proximity Read ↗

Pilin gene variation inNeisseria gonorrhoeae: reassessing the old paradigmsSemantic proximity Read ↗

The comP locus of Neisseria gonorrhoeae encodes a type IV prepilin that is dispensable for pilus biogenesis but essential for natural transformation.Semantic proximity Read ↗

Questions about gonococcal pilus phase‐ and antigenic variationSemantic proximity Read ↗

Modification of type IV pilus-associated epithelial cell adherence and multicellular behavior by the PilU protein of Neisseria gonorrhoeae.Semantic proximity Read ↗

Expression of a Clostridium perfringens Type IV Pilin by Neisseria gonorrhoeae Mediates Adherence to Muscle CellsSemantic proximity Read ↗

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