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Article

Sequence changes in the pilus subunit lead to tropism variation of Neisseria gonorrhoeae to human tissue.

Molecular microbiology - 1 Aug 1994

Jonsson A B, Ilver D, Falk P, Pepose J, Normark S

Abstract excerpt

Pili of Neisseria gonorrhoeae are correlated with increased bacterial attachment to epithelial cells and undergo both phase and antigenic variation. Phase variation of gonococcal pili can be brought about by recombination events in the pilin structural gene, pilE, or by the on/off switch in expression of PilC, a pilus biogenesis protein for which two loci exist. We have studied the binding to epithelial cell...

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Identifiers

PMID: 7997158
DOI: 10.1111/j.1365-2958.1994.tb00435.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Sequence changes in the pilus subunit lead to tropism variation of Neisseria gonorrhoeae to human tissue.PMID 7997158Read ↗

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Neisseria meningitidis undergoes PilC phase variation and PilE sequence variation during invasive disease.Semantic proximity Read ↗

Antigenic variation of gonococcal pilin expression in vivo: analysis of the strain FA1090 pilin repertoire and identification of the pilS gene copies recombining with pilE during experimental human infection The GenBank accession numbers for the sequences reported in this paper are U58840–U58851, U61269, L28978, L28980, L28987 and L28990–L28992.Semantic proximity Read ↗

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