Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus.

doi:10.1128/JVI.69.1.439-445.1995

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Article

Hyperphosphorylation of mutant influenza virus matrix protein, M1, causes its retention in the nucleus.

Journal of virology - 1 Jan 1995

Whittaker G, Kemler I, Helenius A

Abstract excerpt

The matrix (M1) protein of influenza virus is a major structural component, involved in regulation of viral ribonucleoprotein transport into and out of the nucleus. Early in infection, M1 is distributed in the nucleus, whereas later, it is localized predominantly in the cytoplasm. Using immunoflu...

Topics

Amino Acid Sequence
Animals
Biological Transport
Cell Nucleus
Cells, Cultured
Dogs
Isoquinolines
Microscopy, Fluorescence
Molecular Sequence Data
Mutation
Nucleoproteins
Phosphorylation
Protein Kinase Inhibitors
Sulfonamides
Viral Matrix Proteins

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