Article
The polymerase chain reaction detects B cell clonalities in patients with Sjögren's syndrome and suspected malignant lymphoma.
The Journal of rheumatology - 1 Aug 1994
De Vita S, Ferraccioli G, De Re V, Dolcetti R, Carbone A, Bartoli E, Boiocchi M
Abstract excerpt
OBJECTIVE: To investigate the usefulness of the polymerase chain reaction (PCR) to detect B cell clonal expansions in tissues where lymphoproliferative disease was suspected in the course of Sjögren's syndrome (SS). METHODS: Tissue samples from 7 patients with definite (5 cases) or probable (2 ca...
Topics
- Adult
- Aged
- B-Lymphocytes
- Base Sequence
- Blotting, Southern
- Female
- Gene Rearrangement, B-Lymphocyte
- Genes, Immunoglobulin
- Genotype
- Humans
- Immunoglobulin Heavy Chains
- Immunophenotyping
