Article
Regulation of myosin regulatory light chain phosphorylation via cyclic GMP during chemotaxis of Dictyostelium.
Journal of cell science - 1 Jul 1994
Liu G, Newell P C
Abstract excerpt
Previous studies on the chemotactic movement of Dictyostelium have indicated a role for cyclic GMP in regulating the association of myosin II with the cytoskeleton. In this study we have examined the part played by phosphorylation of the 18 kDa myosin regulatory light chain in this event. Using streamer F mutant NP368 (which is deficient in the structural gene for cyclic GMP-specific phosphodiesterase) we find...
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