Article
Genetic epidemiology of vitiligo: multilocus recessivity cross-validated.
American journal of human genetics - 1 Nov 1994
Nath S K, Majumder P P, Nordlund J J
Abstract excerpt
Vitiligo is a dermatological disorder characterized by hypopigmentary patches that tend to become progressive over time. There are reports of extensive familial aggregation. A genetic model for this disorder was earlier proposed by us. This model postulates that recessive alleles at multiple unlinked autosomal loci interact epistatically in the pathogenesis of vitiligo. The present family study was primarily...
Topics
- Adolescent
- Adult
- Age of Onset
- Aged
- Child
- Child, Preschool
- Female
- Genes, Recessive
- Genotype
- Humans
- Male
- Middle Aged
- Models, Genetic