Article
Association of dopamine D2 receptor gene haplotypes with anovulation and fecundity in female Hispanics.
Human reproduction (Oxford, England) - 1 Jul 1994
Legro R S, Dietz G W, Comings D E, Lobo R A, Kovacs B W
Abstract excerpt
Dopamine is an important neurotransmitter in the hypothalamic control of gonadotrophin secretion. Neuron response is mediated through one of five different dopamine receptors. We explored the association of D2 receptor gene polymorphisms with disorders of ovulation. We utilized a multiplex allele specific polymerase chain reaction (PCR) to detect two bi-allelic polymorphisms (four potential haplotypes) in intron...
Topics
- Adult
- Alleles
- Anovulation
- Base Sequence
- DNA Primers
- Dopamine
- Female
- Fertility
- Gene Frequency
- Gonadotropins, Pituitary
- Haplotypes
- Hispanic or Latino