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Article

An androgen receptor mutation causing androgen resistance in undervirilized male syndrome.

The Journal of clinical endocrinology and metabolism - 1 Oct 1994

Tsukada T, Inoue M, Tachibana S, Nakai Y, Takebe H

Abstract excerpt

The molecular basis of androgen resistance was investigated in a patient with undervirilized male syndrome. Binding studies of the androgen receptors in the patient's genital skin fibroblasts revealed a normal binding capacity of 5 alpha-dihydrotestosterone, although the affinity to androgen was slightly lower than the normal control value. The androgen binding of the patient's receptor showed a moderate thermal...

Topics

Adult
Androgens
Base Sequence
Disorders of Sex Development
Drug Resistance
Fibroblasts
Genitalia, Male
Gynecomastia
Humans
Male
Molecular Probes
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Point Mutation

Receptors, Androgen

Skin

Source

Identifiers

PMID: 7962294
DOI: 10.1210/jcem.79.4.7962294

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7962294-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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