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Article

1H NMR investigation of distal mutant deoxy myoglobins. Interpretation of proximal His contact shifts in terms of a localized distal water molecule.

The Journal of biological chemistry - 25 Nov 1994

La Mar G N, Dalichow F, Zhao X, Dou Y, Ikeda-Saito M, Chiu M L, Sligar S G

Abstract excerpt

1H NMR spectra of a series of distal point mutants of human and sperm whale deoxy myoglobin have been recorded and their spectral parameters compared with those of wild type. The substitutions investigated include His64(E7)-->Gly, Ala, Val, Leu, Ile, and Gln and Val68(E11)-->Ala, Ile. The three resonances from the proximal His F8 imidazole ring, as well as two heme methyl signals, are identified in each of the...

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PMID: 7961951

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